SOAT1 in ovarian cancer cells regulates immune response mediated by CD8+ T cells
In conclusion, the present study suggested that SOAT1 inhibition in OC cells could impair the cytotoxic capability of CD8<sup>+</sup> T cells in vitro, probably through the increased secretion of IL-6 and IL-8 in OC cells.
Authors
- Runying Long
- Karen K. L. Chan (ORCID: https://orcid.org/0000-0001-9947-4713)
- Long Hung
- Hys Ngan (ORCID: https://orcid.org/0000-0003-3945-159X)
- Ruiqian Zhang (ORCID: https://orcid.org/0000-0002-2088-8911)
- Jiangnan He (ORCID: https://orcid.org/0000-0002-4192-546X)
- Mingo M. H. Yung (ORCID: https://orcid.org/0000-0003-0903-1164)
- Haonan Lu (ORCID: https://orcid.org/0000-0002-2472-7488)
- Michelle K.Y. Siu (ORCID: https://orcid.org/0000-0002-5730-6073)
Institutions
- Institut de Recherche et d’Innovation (FR)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1186/s13048-025-01832-x
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00