Mechanistic basis for the opposing effects of H2A and H2B ubiquitination on nucleosome stability and dynamics
Our findings quantitatively explain how H2A and H2B ubiquitination exert opposing effects on chromatin regulation. This mechanism is directly relevant to the opposing roles of these marks in transcriptional activation and repression, and may represent one way that combinations of histone modifications modulate chromatin function in vivo.
Authors
- Lokesh Baweja (ORCID: https://orcid.org/0000-0003-1078-8914)
- Jeff Wereszczynski (ORCID: https://orcid.org/0000-0002-2218-3827)
Institutions
- Illinois Institute of Technology (US)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1186/s13072-025-00635-0
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00