Total syntheses of highly oxidative <i>Ryania</i> diterpenoids facilitated by innovations in synthetic strategies

Innovations in synthetic methods and strategic design serve as the primary driving forces behind the advancement of organic synthetic chemistry. With rapidly evolving organic synthesis technologies, a diverse array of novel methods and sophisticated strategies continues to emerge. These approaches not only complement and synergize with one another but also significantly enhance synthetic efficiency, reduce costs, and provide robust solutions to challenges encountered in the synthesis of complex molecular architectures. <i>Ryania</i> diterpenes are natural products characterized by intricate structures and high oxidation states. Biological studies have revealed that the family member ryanodine has a specific regulatory effect on myocardial calcium ion channels (PyR). Since only a limited number of compounds have been reported to act by modifying this receptor, ryanodine and its derivatives are potential therapeutic agents for treating cardiovascular diseases. This article focuses on reviewing the efficient application of ring-construction methods and synthetic strategies in the total synthesis of highly oxidized <i>Ryania</i> diterpenoid natural products, emphasizing the pivotal role of novel synthetic methods and strategic innovations.