Parkinson's‐Linked <i>LRRK2</i> and <i>GBA1</i> Mutations Modulate the Peripheral Immune Response to <i>Pseudomonas aeruginosa</i>
This work demonstrates that PD-linked mutations in LRRK2 and GBA1 converge on peripheral blood immune cell dysregulation, as evinced by the ability of LRRK2 inhibitors and GCase activators to modulate the ex vivo immune response to bacterial exposure. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Alícia Garrido (ORCID: https://orcid.org/0000-0003-0652-6348)
- Malu Gámez Tansey (ORCID: https://orcid.org/0000-0002-1719-4708)
- Nicolas Dzamko (ORCID: https://orcid.org/0000-0002-9121-0294)
- Julian Agin‐Liebes (ORCID: https://orcid.org/0000-0002-1675-7142)
- Ann M. Titus (ORCID: https://orcid.org/0000-0002-1293-1350)
- Julian R Mark (ORCID: https://orcid.org/0000-0003-4152-7725)
- Laura P. Hughes
- Rebecca Wallings (ORCID: https://orcid.org/0000-0003-3878-291X)
- Hannah A. Staley (ORCID: https://orcid.org/0009-0001-8284-6178)
Institutions
- The University of Sydney (AU)
- New South Wales Department of Health (AU)
- Duke University (US)
- Neurosciences Institute (US)
- Columbia University Irving Medical Center (US)
- University of Florida (US)
- Hospital Clínic de Barcelona (ES)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Trinity College (US)
- Florida College (US)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1002/mds.70123
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39