TIGIT/SHIP-1/RelB regulating Th1 inflammation in smoking induced COPD
In smoking-induced COPD, TIGIT/SHIP-1 affects the activation of RelB through the PI3K/AKT pathway, thereby regulating the expression of Th1. It offers insights underlying the immune mechanism of COPD.
Authors
- Minchao Duan (ORCID: https://orcid.org/0000-0001-5434-5555)
- Zhixiong He (ORCID: https://orcid.org/0000-0001-5243-7907)
- Langhuan Lei
- Yinying Li (ORCID: https://orcid.org/0009-0007-2432-7023)
- Junyi Ke
- Siyu Lei
- Qinglan Li (ORCID: https://orcid.org/0000-0002-6912-1156)
- Shu Huang (ORCID: https://orcid.org/0009-0008-7533-2903)
- Yaohui Wu (ORCID: https://orcid.org/0000-0002-9888-3731)
- Lei Lü (ORCID: https://orcid.org/0000-0001-5275-2181)
- Hongchun Huang
- Shiya Lin
Institutions
- Guangxi Medical University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1186/s12931-025-03400-9
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00