Similar DTI-ALPS metrics in Parkinson’s disease and essential tremor: a cross-sectional comparative analysis
Both PD (mean ALPS = 1.34 ± 0.19) and ET ( 1.31 ± 0.13) groups exhibited 12 significantly lower ALPS values than HC ( 1.54±0.11 P < 0.05), but no difference was 13 found between PD and ET. In PD, lower ALPS correlated with greater tremor severity and older age, particularly in the right hemisphere (R²=0.80, p=0.003). ET showed weaker clinical associations though MoCA correlated positively with right-hemisphere ALPS (ρ=0.462, p=0.018). CONCLUSION: The findings indicate perivascular diffusivity is reduced in both tremor-dominant PD and ET, supporting a role for glymphatic dysfunction in their pathophysiology, though larger, prospective studies are needed to validate this observation.
Authors
- Patrizia Sucapane
- Pierpaolo Palumbo (ORCID: https://orcid.org/0000-0003-1514-0092)
- Leonardo Pertici (ORCID: https://orcid.org/0000-0002-1034-9922)
- Francesco Arrigoni (ORCID: https://orcid.org/0000-0001-7793-1872)
- Francesca Pistoia (ORCID: https://orcid.org/0000-0003-0790-4240)
- Alessandra Splendiani (ORCID: https://orcid.org/0000-0002-2188-3506)
- Gennaro Saporito (ORCID: https://orcid.org/0009-0001-2390-0533)
- Antonio Innocenzi
- Ernesto Di Cesare (ORCID: https://orcid.org/0000-0002-0995-3081)
- Alessia Catalucci
- Chiara Santobuono
- Pierfrancesco Badini
- Antonio Barile (ORCID: https://orcid.org/0000-0003-0253-3583)
- Bruno Federico (ORCID: https://orcid.org/0000-0002-8629-4366)
- Marco Cella
Institutions
- University of L'Aquila (IT)
- San Salvatore Hospital (IT)
Publication Details
- Journal
- Neuroradiology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1007/s00234-025-03840-6
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00