The monitoring role of non-invasive examinations on the clinical efficacy of photodynamic therapy for oral potentially malignant disorders

This study assesses clinical efficacy of 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) for treating oral potentially malignant disorders (OPMDs) and explores the utility of toluidine blue staining and autofluorescence examination in monitoring treatment efficacy. Seventy-five OPMD patients treated with 5-ALA-PDT were followed up. Lesion size and clinical presentation were recorded, while toluidine blue staining and autofluorescence were used to monitor treatment and diagnose oral epithelial dysplasia. Toluidine blue staining had a sensitivity of 62.2% and specificity of 42.9%, while autofluorescence showed a sensitivity of 67.2% and specificity of 64.3%. Combined, sensitivity increased to 77%, and specificity to 71.4%. After 5-ALA-PDT, 38.7% of patients achieved complete remission. Overall response rate was 92%. Persistent positive staining correlated with treatment failure. Clinical efficacy was lower in patients with worsening results in both examinations. 5-ALA-PDT is effective for OPMDs, and toluidine blue staining and autofluorescence are valuable tools for diagnosing and monitoring treatment progress.

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Publication Details

Journal
Photodiagnosis and Photodynamic Therapy
Published
2025-11-01
DOI
https://doi.org/10.1016/j.pdpdt.2025.104916
Primary Topic
Photodynamic Therapy Research Studies
Type
article
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article

The monitoring role of non-invasive examinations on the clinical efficacy of photodynamic therapy for oral potentially malignant disorders

Xinyi Ni, Shufang Li, Yutian Wang, Hongmei Cui et al.
Photodiagnosis and Photodynamic Therapy
Photodynamic Therapy Research Studies
article

The monitoring role of non-invasive examinations on the clinical efficacy of photodynamic therapy for oral potentially malignant disorders

Xinyi Ni, Shufang Li, Yutian Wang, Hongmei Cui, Xiang Guo, Mingxing Lu, Qianyun Guo, Xu Si, Xiaodan Liu, Zhe Cheng, Qian Wang, Jianqiu Jin, Wenwen Li, Xing Wang, Hongwei Liu, Lei Zhang, Zijian Liu, Xingyun Liu, Ying Han
article en

Abstract

This study assesses clinical efficacy of 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) for treating oral potentially malignant disorders (OPMDs) and explores the utility of toluidine blue staining and autofluorescence examination in monitoring treatment efficacy. Seventy-five OPMD patients treated with 5-ALA-PDT were followed up. Lesion size and clinical presentation were recorded, while toluidine blue staining and autofluorescence were used to monitor treatment and diagnose oral epithelial dysplasia. Toluidine blue staining had a sensitivity of 62.2% and specificity of 42.9%, while autofluorescence showed a sensitivity of 67.2% and specificity of 64.3%. Combined, sensitivity increased to 77%, and specificity to 71.4%. After 5-ALA-PDT, 38.7% of patients achieved complete remission. Overall response rate was 92%. Persistent positive staining correlated with treatment failure. Clinical efficacy was lower in patients with worsening results in both examinations. 5-ALA-PDT is effective for OPMDs, and toluidine blue staining and autofluorescence are valuable tools for diagnosing and monitoring treatment progress.

Photodiagnosis and Photodynamic TherapyVol. 56
King University (US), Peking University (CN)
Openalex Percentile: Top 50%
Photodynamic Therapy Research Studies
DOIOpen Access PDFOpenAlex
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