Evaluation of Long-term Efficacy of 5-ALA-PDT for Oral Potentially Malignant Disorders: A Cohort Study
To evaluate the long-term efficacy of 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) in oral potentially malignant disorders (OPMDs). A prospective cohort study was conducted on 84 OPMD patients treated with 5-ALA-PDT, followed up for at least 1 year for recurrence and malignant transformation. A matched retrospective control group of untreated patients was also included. The median follow-up was 38 months, with a total recurrence rate of 51.1% and a malignant transformation rate of 30.9%. Multivariate analysis showed that non-smokers and those without post-treatment swelling had higher recurrence rates. Female gender, baseline pain symptoms, and lesion recurrence were linked to a higher risk of malignant transformation. Kaplan-Meier analysis indicated faster cancer onset in the control group (P=0.041). 5-ALA-PDT effectively delays malignant transformation in OPMDs, with better outcomes in high-risk lesions and certain patient characteristics.
Authors
- Hongmei Cui (ORCID: https://orcid.org/0000-0002-9307-3019)
- Xiaodan Liu (ORCID: https://orcid.org/0000-0003-1500-9086)
- Yu Tian Wang (ORCID: https://orcid.org/0000-0001-8592-0698)
- Mingxing Lu (ORCID: https://orcid.org/0000-0003-4383-5107)
- Xu Si (ORCID: https://orcid.org/0000-0002-5667-1503)
- Z Liu (ORCID: https://orcid.org/0009-0000-2651-9159)
- Xiang Guo (ORCID: https://orcid.org/0009-0008-4207-3327)
- Zhe Cheng (ORCID: https://orcid.org/0000-0002-9127-241X)
- Jianqiu Jin (ORCID: https://orcid.org/0000-0001-9730-8228)
- Qian Wang
- Xing Wang (ORCID: https://orcid.org/0000-0002-3037-8907)
- Hongwei Liu (ORCID: https://orcid.org/0000-0001-5685-496X)
- Lei Zhang (ORCID: https://orcid.org/0000-0001-6641-7245)
- Shufang Li (ORCID: https://orcid.org/0000-0002-2371-8125)
- Xingyun Liu (ORCID: https://orcid.org/0000-0003-3590-1370)
- Ying Han (ORCID: https://orcid.org/0000-0003-2158-6699)
- Qianyun Guo (ORCID: https://orcid.org/0000-0002-8805-9271)
- Wenwen Li (ORCID: https://orcid.org/0009-0006-5973-5169)
Institutions
- King University (US)
- Peking University (CN)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.pdpdt.2025.104918
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00