Clinical Efficacy and Wound Management Insights of ALA-PDT for Extensive Bowen's Disease of the Lower Extremity: A Case Study

This case report describes the successful application of aminolevulinic acid photodynamic therapy (ALA-PDT) combined with advanced wound care strategies in a 75-year-old male with diabetes and coronary artery disease presenting with extensive Bowen's disease (4 × 4 cm) on the left lower extremityKey insights highlight: 1) ALA-PDT as a tissue-sparing alternative to surgical excision for high-risk geriatric patients, avoiding skin grafting; 2) Synergistic wound care combining antimicrobial, exudate-control, and microenvironment-optimizing modalities; 3) Effective pain mitigation through topical anesthetics and mechanical protection strategies. This multidisciplinary approach demonstrates robust oncological control with preserved functional integrity, offering a replicable framework for managing extensive Bowen's disease in comorbid populations.