Organ transplant recipients’ attitudes toward photodynamic therapy for actinic keratosis: A survey from Imperial College NHS Trust dermatology transplant clinic

Organ transplant recipients (OTRs) face a significantly higher risk of non-melanoma skin cancers (NMSCs). Conventional treatments like cryotherapy and topical therapies pose challenges due to large treatment areas, cosmetic concerns, and frequent sessions. Photodynamic therapy (PDT) is a promising alternative, but traditional PDT can be painful, reducing patient compliance. Indoor daylight PDT (DL-PDT) offers a well-tolerated, year-round option. An online survey was sent to patients attending a tertiary dermatology transplant clinic in the United Kingdom, and assessed patient preferences, perceptions of PDT, and willingness to participate in a randomized controlled trial (RCT) of cyclic indoor DL-PDT for actinic keratosis (AK) prevention. Among 30 respondents, 97% supported indoor DL-PDT, and 93% were interested in preventive therapy. SCC prevention (90%) and treatment efficacy (83%) were key priorities. High patient interest supports further RCTs on DL-PDT as a preventive strategy for AK and SCC in high-risk OTRs