Synergistic Photothermal and Chemo-Therapeutic Platform Utilizing Cu2-xSe/PDA/AIPH Nanoparticles for Targeted Tumor Eradication

In this study, we developed a novel Cu 2-x Se/PDA/AIPH nanoparticle platform that synergizes photothermal therapy (PTT) with controlled reactive oxygen species (ROS) generation for effective cancer treatment. The Cu 2-x Se nanoparticles, known for their strong near-infrared (NIR) absorption, were encapsulated within a polydopamine (PDA) and 2, 2’-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIPH) matrix. Upon NIR irradiation, the platform triggers localized heating and subsequent thermal decomposition of AIPH, releasing ROS to induce significant oxidative damage in tumor cells. In vitro and in vivo experiments demonstrated that Cu 2-x Se/PDA/AIPH nanoparticles exhibit excellent biocompatibility, effective photothermal conversion, and potent anticancer efficacy. This multifunctional nanosystem offers a promising approach for enhancing cancer therapy by combining PTT with ROS-mediated chemotherapy.