Cognitive Impairment in Temporal Lobe Epilepsy: Alterations in the Basal Forebrain Cholinergic System
TLE patients exhibit cognitive and visual-spatial memory deficits, with BFCS tract damage being more pronounced in LTLE and HS patients. The BFCS and its projection fibers demonstrate potential correlations with cognitive function and may be involved in the neural mechanisms of cognitive impairment in TLE.
Authors
- Jiajia Fang (ORCID: https://orcid.org/0000-0002-8549-8009)
- Bofei Chen
- Yi Shi (ORCID: https://orcid.org/0000-0003-3005-9655)
- Zhu Qiu (ORCID: https://orcid.org/0009-0004-1320-2151)
- Lina Jiang (ORCID: https://orcid.org/0000-0003-0404-1179)
- Shuang Wang (ORCID: https://orcid.org/0000-0002-5558-4029)
- Jiahui Guo (ORCID: https://orcid.org/0009-0006-1522-0120)
- Beibei Shen
- Zhefeng Yuan
Institutions
- Zhejiang International Studies University (CN)
- Children's Hospital of Zhejiang University (CN)
- Third People's Hospital of Huzhou (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/brb3.71090
- Citations
- 1
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Natural Science Foundation of China
- Zhejiang University