Long term follow up for Bowen disease after Photodynamic Therapy

Bowen’s disease (BD) represents the in situ form of cutaneous squamous cell carcinoma; although it has an excellent prognosis, 3–5% of lesions progress to invasive cutaneous squamous cell carcinoma. Photodynamic Therapy(PDT) can be a treatment option mainly for large extension lesions, providing an excellent rates of recurrence free follow up. Patients with an histological diagnostic of BD from 2017 to 2020 were treated with red light PDT in a single visit protocol. The clinical evaluation was performed 30 days after PDT, and avery 6 months thereafter until December 2024. The area of the initial lesions ranged from 5 to 75 mm, with a mean of 26.2mm. Considering that these large area lesions would be treated with surgical procedure, the PDT treatment showed 80.4% of 5 years recurrence free follow-up. This study shows an important contribution of PDT treatment of large area lesions, avoiding surgeries of big reconstructions in old patients with comorbidities.