Ultrasonic Scalpel Surgery combined with Photodynamic Therapy Versus Trichloroacetic Acid Application in Treating HPV-Related Condyloma Acuminata

Genital infection with Human Papillomavirus (HPV) is a disease that affects a large fraction of the world's population. Condylomata acuminata or anogenital warts are benign lesions that are part of the clinical infection caused by low-risk HPVs, such as HPV6 or HPV11. This randomized clinical study, aimed to evaluate the efficacy of two different therapeutic approaches in treating genital lesions induced by HPV. Group 1, with 18 patients, received an innovative treatment combining lesion excision with an ultrasonic scalpel followed by photodynamic therapy (US+PDT). Group 2, with 18 patients, underwent standard treatment with 80% trichloroacetic acid (TCA). The US+PDT group required fewer treatment sessions, exhibited superior cosmetic outcomes, and reported zero lesion recurrence during an 18-month follow-up, in contrast to the TCA group’s recurrence rate of 33.3%.