Photodynamic Therapy for Facial Port-Wine Stain in a 2-Year-Old Boy

Port-wine stains (PWS) are challenging vascular malformations with significant cosmetic and psychosocial implications, especially in young children. Early and effective treatment is crucial to minimize long-term impact. A 2-year-old boy presented with PWS involving the right cheek, forehead, and periocular area. Ophthalmologic evaluation ruled out glaucoma and Sturge-Weber syndrome. The patient underwent photodynamic therapy (PDT) using a photosensitizing agent and targeted light activation. After the first PDT session, the lesion demonstrated 50% resolution. Following a second treatment, near-complete clearance of the PWS was achieved. The outcomes were cosmetically satisfactory, with no adverse effects or recurrence observed to date. PDT proved to be a safe and effective treatment for pediatric PWS, achieving substantial lesion clearance with minimal side effects. This case underscores the potential of PDT as a valuable therapeutic option for early intervention in PWS, warranting further investigation and protocol optimization.