Effect of photodynamic therapy with hypericin on the secretion of selected progression factors by colorectal cancer cells
The purpose of this study was to determine the role of HYP-PDT and its cytotoxic and immunomodulatory efficacy in the treatment of colorectal cancer, assessed on colon cancer cells. Two colon cancer cell lines were used in this experiment: SW480 and SW620, that were treated with HYP-PDT . After HYP-PDT treatment, changes in the concentrations of GM-CSF, MFI, VCAM-1, ICAM-1 and IL-2, IL-4, IL6 were analyzed. For SW480 cells: after HYP-PDT, there was a marked decrease in the secretion of GM-CSF, MIF, VCAM-1 and ICAM-1. For SW620 cells after HYP-PDT: there was no effect on GM-CSF secretion; HYP-PDT inhibited the secretion of VCAM-1 and MIF and stimulated the secretion of ICAM-1 by the cells tested. The applied HYP-PDT showed no effect on the secretion of IL-2, IL-4 and IL-6 by the cell lines. HYP-PDT shows cytotoxic and immunomodulatory potential on colon cancer cells.
Authors
- Wojciech Latos (ORCID: https://orcid.org/0000-0003-1577-3105)
- Grzegorz Cieślar (ORCID: https://orcid.org/0000-0003-2210-8744)
- David Aebisher (ORCID: https://orcid.org/0000-0002-2661-6570)
- Anna Międzybrodzka (ORCID: https://orcid.org/0000-0001-8827-7220)
- Piotr Oleś (ORCID: https://orcid.org/0000-0001-7520-1315)
- Małgorzata Kłósek (ORCID: https://orcid.org/0000-0002-9266-2292)
- Magdalena Krupka-Olek (ORCID: https://orcid.org/0000-0003-4177-8102)
- Aleksandra Kawczyk‐Krupka (ORCID: https://orcid.org/0000-0003-1284-3809)
- Zenon Paweł Czuba (ORCID: https://orcid.org/0000-0001-8216-4495)
- Magdalena Czarnecka–Czapczyńska
- Dorota Bartusik‐Aebisher (ORCID: https://orcid.org/0000-0002-5557-5464)
Institutions
- Medical University of Silesia (PL)
- University of Bielsko-Biała (PL)
- University of Silesia in Katowice (PL)
- University of Rzeszów (PL)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.pdpdt.2025.104851
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00