Value of laser, photodynamic therapy, and follow-up observation in the management of cervical low-grade squamous intraepithelial lesions: a prospective cohort study

To explore the value of CO2 laser, photodynamic therapy, and follow-up observationin the management of cervical low-grade squamous intraepithelial lesions (LSIL). Women diagnosed with cervical LSIL and high risk human papillomavirus(HR-HPV) infection were collected and the complete remission rate(CRR) and HR-HPV clearance rate were compared during the 6-12 month follow-up. At the 6-12 month follow-up, the CRR was 89.7% in the laser group, slightly higher than the 86.9% in the photodynamic group, P=0.523. However, both were significantly higher than the 64.4% in the follow-up group. The HR-HPV clearance rates in the laser and photodynamic groups were 73.8% and 68.2%, respectively, both significantly higher than the 32.7% in the follow-up group, with no statistical difference between the laser and photodynamic groups, P=0.366. CO2 laser and photodynamic therapy are effective treatments for cervical LSIL, significantly superior to follow-up observation in terms of CRR and HPV clearance rates.