Personalized high-grade CIN treatment with photodynamic therapy and preventing cervical cancer

Cervical Intraepithelial Neoplasia (CIN) is the precursor of cervical cancer, the fourth most common cancer in women globally. Excisional techniques such as high-frequency surgery are recommended but can carry risk to woman and a future pregnancy. This clinical trial offers an individualized treatment with Photodynamic Therapy (PDT), starting with two PDT sessions, 21 days apart and performing colposcopy and hybrid capture 90 days after the 1st session. The patient will continue with two other sessions of PDT if the viral load of high-risk HPV has decreased by at least 50%. The most promising protocol in a previously clinical trial presents benefits with two PDT sessions twenty-one days apart. The results will now be complemented with PCR, p16 and Ki-67. Two PDT sessions with a 21-day interval have shown promise for colposcopic findings favorable to cure, as well as for reducing viral load by more than 50%.