Design of Dinuclear Osmium Complex Doped Antifouling Cellulose Nanoparticles for Targeting and Dual Photodynamic / photothermal Therapy under Near Infrared Irradiation

Transition metal-ligand has been explored in the treatment of tumors in photodynamic theray or photothermal therapy and Osmium complex attracts attentration due to its lower toxicity and longer absorption wavelength. Herein, we synthesis of mono/dinuclear Os complexes (OsY1, OsY2) with dual PDT/PTT capabilities under a single near-infrared (NIR) excitation wavelength. These features arise from the large p-conjugated structure of our dinuclear Os complex coupled with efficient metal-to-ligand charge transfer. Furthermore, we prepared the Osmium complex-doped, aptamer-conjugated cellulose NPs via the emulsion polymerization method. These NPs exhibit a notable ability to target mitochondria and posse a "protein corona-free" status, showing much higher efficiency in tumor ablation (76%) than the commercialized indocyanine green (ICG) doped cellulose NPs (24%) under 808 nm irradiation.Consequently, our designed mono/dinuclear Os complex, featuring a single-molecule dual PDT/PTT effect within doped antifouling NPs, holds promise for potential applications in cancer therapy.