Efficacy of Photodynamic Therapy as an Adjunctive Treatment for Cervical HSIL Patients with Positive Margins after LEEP

Cervical high-grade squamous intraepithelial lesions (HSIL) often persist following incomplete excision during loop electrosurgical excision procedures (LEEP). Adjunctive photodynamic therapy (PDT) may enhance lesion clearance and HPV suppression. A comparative study evaluated PDT following LEEP in HSIL patients with positive surgical margins. HPV clearance and disease regression were assessed at 3 months post-treatment. Statistical analysis used Fisher’s exact test. The PDT group (n=14) showed a 71.43% HPV clearance rate (10/14) compared to 55.56% (5/9) in the control group (P=0.4857). Disease regression was significantly higher in the PDT group, with 92.86% (13/14) achieving disease-free or downgraded status compared to 66.67% (6/9) in the control group (P=0.04545). PDT as an adjunct to LEEP significantly improves disease regression in HSIL patients with positive margins, despite no significant impact on HPV clearance.