Efficacy of ALA-PDT on Cervical Low-Grade Squamous Intraepithelial Lesions in Different Transformation Zones

The study investigated the clinical efficacy of Photodynamic therapy (PDT) mediated by 5-aminolevulinic acid (5-ALA) for cervical low-grade squamous intraepithelial lesion with different types of transformation zones. A retrospective study was performed on 98 patients with histologically confirmed cervical low-grade squamous intraepithelial lesion and receiving 5-ALA PDT. All patients were followed up at 3-6 months after treatment, effect was evaluated by cotesting of HPV extended genotyping and liquid-based cytology and coloposcopy. Complete remission included cervical LSIL resolution and negative HPV testing. The total complete remission (CR) rate was 78.54% (77/98) at 3-6 months after treatment. The CR rates for the SCJ3, SCJ2, and SCJ1 groups were 75.00%, 84.21%, and 81.48%, respectively. There was no statistically significant difference in the CR rate between the SCJ3 group and the SCJ2 and SCJ1 groups (p>0.05). Our study demonstrates that 5-ALA-PDT is highly effective in treating cervical intraepithelial neoplasia across different transformation zones.