Efficacy of ALA-PDT and CO2 laser in the treatment of high-grade vaginal intraepithelial neoplasia
To compare the efficacy and safety of ALA-PDT and CO2 Laser in the treatment of high-grade VaIN. A retrospective review was conducted on 59 patients with high grade VaIN who were treated by ALA-PDT (n=21) or CO2 Laser (n=28) in Peking University People's Hospital from January 2023 to September 2024. After treatment patients were followed up at 3 and 6 months afterwards. (1) The clinical characteristics of patients in the two groups were similar. (2) At 3 and 6 months after treatment in ALA-PDT group, the overall complete remission (CR) rates were similar to that in CO2 Laser group and The total HPV clearance rates were significantly high in ALA-PDT group. (2) The incidence of the adverse events(AE) in ALA-PDT group was lower than that in CO2 laser group. ALA-PDT has equivalent lesion reversal rates and superior HPV clearance compared with CO2 laser in the treatment of high-grade VaIN.
Authors
- Lihui Wei (ORCID: https://orcid.org/0000-0002-2478-8790)
- Jingran Li (ORCID: https://orcid.org/0000-0003-3096-7581)
- Yun Zhao (ORCID: https://orcid.org/0000-0002-2323-2926)
- Chao Zhao (ORCID: https://orcid.org/0000-0001-7349-306X)
- Mingzhu Li (ORCID: https://orcid.org/0009-0003-4514-4155)
- Lijun Zhao (ORCID: https://orcid.org/0000-0002-0193-3860)
Institutions
- Peking University (CN)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.pdpdt.2025.105178
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00