One More Opportunity in Early-Stage Cervical Cancer: The Role of Photodynamic therapy in Managing Positive Surgical Margins

The investigation into the role of photodynamic therapy (PDT) in treating early cervical cancer, both as a primary modality and as an adjuvant for positive surgical margins, is of paramount significance and clinical relevance. This study evaluates the recurrence of SILs and HPV infection in a cohort of patients with early-stage cervical cancer treated by PDT. The better result of PDT was achieved in the group of patients with partial response after PDT (more than 90%) for both study groups. This demonstrates that PDT based on chlorin e6 is highly effective to remove SILs or residual tumors. This research holds the promise of transforming management strategies, offering a less invasive, fertility-sparing, and highly effective treatment option that could profoundly improve outcomes and quality of life for countless women worldwide.

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Publication Details

Journal
Photodiagnosis and Photodynamic Therapy
Published
2025-11-01
DOI
https://doi.org/10.1016/j.pdpdt.2025.104919
Primary Topic
Photodynamic Therapy Research Studies
Type
article
Field-Weighted Citation Impact
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article

One More Opportunity in Early-Stage Cervical Cancer: The Role of Photodynamic therapy in Managing Positive Surgical Margins

Т. Г. Гришачева, Alexander Dushkin, Irina Dushkina, Alexander Viktorovich Karaulov et al.
Photodiagnosis and Photodynamic Therapy
Photodynamic Therapy Research Studies
article

One More Opportunity in Early-Stage Cervical Cancer: The Role of Photodynamic therapy in Managing Positive Surgical Margins

Т. Г. Гришачева, Alexander Dushkin, Irina Dushkina, Alexander Viktorovich Karaulov, S. S. Afanasiev, M. S. Afanasiev, Nasrulla Shanazarov, A.Yе. Khangeldi
article en

Abstract

The investigation into the role of photodynamic therapy (PDT) in treating early cervical cancer, both as a primary modality and as an adjuvant for positive surgical margins, is of paramount significance and clinical relevance. This study evaluates the recurrence of SILs and HPV infection in a cohort of patients with early-stage cervical cancer treated by PDT. The better result of PDT was achieved in the group of patients with partial response after PDT (more than 90%) for both study groups. This demonstrates that PDT based on chlorin e6 is highly effective to remove SILs or residual tumors. This research holds the promise of transforming management strategies, offering a less invasive, fertility-sparing, and highly effective treatment option that could profoundly improve outcomes and quality of life for countless women worldwide.

Photodiagnosis and Photodynamic TherapyVol. 56
Sechenov University (RU), First Pavlov State Medical University of St. Petersburg (RU), Moscow City Hospital No 29 (RU), City Clinical Hospital (RU), Gabrichevsky Institute of Epidemiology and Microbiology (RU), Astana Medical University (KZ), Global Health Research Center of Central Asia (KZ), Moscow City Oncology Hospital №62 (RU)
Openalex Percentile: Top 50%
Photodynamic Therapy Research Studies
DOIOpen Access PDFOpenAlex
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One More Opportunity in Early-Stage Cervical Cancer: The Role of Photodynamic therapy in Managing Positive Surgical Margins — Т. Г. Гришачева, Alexander Dushkin, et al. · Photodiagnosis and Photodynamic Therapy (2025) | TGRS Research Map | TGRS