A case of actinic keratosis treated by CO₂ ultra-pulsed laser combined with photodynamic therapy

To observe the clinical efficacy of CO₂ super-pulsed laser combined with photodynamic therapy in the treatment of actinic keratosis (AK). Gauze soaked in 0.9% sodium chloride solution was applied to the scab area to soften and remove it. CO₂ super-pulsed laser was used for pretreatment. 5-aminolevulinic acid was applied to the lesion and the surrounding 1 cm of skin, and then covered in the dark for 3 hours. The LED-IB treatment instrument was used for irradiation for 20 minutes, once a week, for a total of 4 treatments. The lesions completely disappeared. CO₂ super-pulsed laser combined with ALA-PDT can improve the therapeutic effect of AK patients and has good safety, which is worthy of promotion.

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Publication Details

Journal
Photodiagnosis and Photodynamic Therapy
Published
2025-11-01
DOI
https://doi.org/10.1016/j.pdpdt.2025.105034
Primary Topic
Nonmelanoma Skin Cancer Studies
Type
article
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article

A case of actinic keratosis treated by CO₂ ultra-pulsed laser combined with photodynamic therapy

Zhangqian Chang
Photodiagnosis and Photodynamic Therapy
Nonmelanoma Skin Cancer Studies
article

A case of actinic keratosis treated by CO₂ ultra-pulsed laser combined with photodynamic therapy

Zhangqian Chang
article en

Abstract

To observe the clinical efficacy of CO₂ super-pulsed laser combined with photodynamic therapy in the treatment of actinic keratosis (AK). Gauze soaked in 0.9% sodium chloride solution was applied to the scab area to soften and remove it. CO₂ super-pulsed laser was used for pretreatment. 5-aminolevulinic acid was applied to the lesion and the surrounding 1 cm of skin, and then covered in the dark for 3 hours. The LED-IB treatment instrument was used for irradiation for 20 minutes, once a week, for a total of 4 treatments. The lesions completely disappeared. CO₂ super-pulsed laser combined with ALA-PDT can improve the therapeutic effect of AK patients and has good safety, which is worthy of promotion.

Photodiagnosis and Photodynamic TherapyVol. 56
Peking University (CN), Peking University First Hospital (CN)
Openalex Percentile: Top 54%
Nonmelanoma Skin Cancer Studies
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