Influence of the degree of tumor resection on cerebral edema and prognosis after photodynamic therapy for gliomas

To investigate the influence of different degrees of tumor resection on cerebral edema and prognosis after photodynamic therapy (PDT) for high-grade glioma. A retrospective case-control study was conducted for the patients with high-grade glioma who underwent PDT and microsurgery in Zhejiang Provincial People’s Hospital from January 2020 to December 2022. There were 30 cases in the near-total resection group and 26 cases in the subtotal resection group. The statistical analysis showed that the patients receiving photodynamic-assisted near-total resection had a lower degree of postoperative cerebral edema, as well as significantly better progression-free survival. The multimodality therapy with PDT and near-total resection can significantly reduce the degree of cerebral edema in patients with highgrade glioma and help to improve postoperative quality of life, inhibit tumor recurrence, and prolong the overall survival of patients.