Electrocoagulation Combined with Photodynamic Therapy for Moderately to Well-Differentiated Cutaneous Squamous Cell Carcinoma: A Case Series of 10 Elderly Patients

Traditional surgical approaches and single minimally invasive therapies suffer from limitations such as high invasiveness or insufficient efficacy, failing to meet the treatment needs of elderly patients with cutaneous squamous cell carcinoma (cSCC). To address this challenge, we developed an innovative minimally invasive strategy combining electrocoagulation and photodynamic therapy (PDT). Tumor tissues were removed via high-frequency electrocoagulation in 10 elderly patients with moderately to well-differentiated cSCC, followed by aminolevulinic acid-based PDT administered at least three times. Post-treatment follow-up focused on local aesthetic recovery, functional preservation, and tumor recurrence. After combined therapy, all patients achieved complete tumor clearance with preserved local appearance and function. No recurrence was observed during a follow-up period exceeding six months. The combination of electrocoagulation and PDT proves effective, minimally invasive, and convenient for treating moderately to well-differentiated cSCC, particularly in elderly patients. This dual approach warrants broader clinical adoption.