Development of Acellular Hepatic Scaffolds Through a Low-Cost Gravity-Assisted Perfusion Decellularization Method
This low-cost, reproducible, and technically simple system enables the generation of high-quality acellular hepatic scaffolds without mechanical pumps. Its accessibility and scalability make it suitable for laboratories with limited infrastructure and educational settings. Moreover, this gravity-assisted approach provides a foundation for future recellularization and preclinical studies aimed at developing bioengineered liver constructs for regenerative and transplant applications.
Authors
- Carlos Arzate-Quintana (ORCID: https://orcid.org/0000-0002-5673-5992)
- Alva Rocío Castillo-González (ORCID: https://orcid.org/0000-0002-2471-2489)
- Luis Carlos Hinojos-Gallardo (ORCID: https://orcid.org/0009-0000-4229-5140)
- Alfredo Nevárez-Rascón (ORCID: https://orcid.org/0009-0001-9600-1694)
- María Alejandra Favila-Pérez
- Luis Bernardo Enríquez-Sánchez (ORCID: https://orcid.org/0000-0001-9143-3626)
- Celia María Quiñonez-Flores (ORCID: https://orcid.org/0000-0003-0740-5783)
- Víctor A. Ríos-Barrera
- Manuel David Pérez Ruíz (ORCID: https://orcid.org/0000-0002-2729-1579)
- María Fernanda Duarte-Ortega
Institutions
- Autonomous University of Chihuahua (MX)
Publication Details
- Journal
- Biomimetics
- Published
- 2025-11-15
- DOI
- https://doi.org/10.3390/biomimetics10110777
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad Autónoma de Chihuahua