Severe Allergic Drug Reaction to Ultrasound Enhancing Agent Resulting in Cardiogenic Shock
Observational data have shown that ADR to UEA has become more prevalent in the past several years, with higher rates with Lumason vs Definity. It is important to monitor patients who have ADRs to UEA and who are treated with epinephrine, especially those with underlying cardiomyopathy, as there is potential for a transition from anaphylaxis to stress cardiomyopathy and cardiogenic shock. Given the risk for significant ADR, UEA should be used selectively and only as needed.
Authors
- Lori B. Croft (ORCID: https://orcid.org/0000-0003-3962-8922)
- Caroline R. Gross (ORCID: https://orcid.org/0000-0002-8838-6950)
- Alexander Levy (ORCID: https://orcid.org/0000-0003-3620-0154)
- Matthew Cagliostro
- Kyle A. Nelson (ORCID: https://orcid.org/0000-0002-1522-8548)
- Stamatios Lerakis (ORCID: https://orcid.org/0000-0001-7487-1990)
- Jason Feinman (ORCID: https://orcid.org/0000-0001-7964-1502)
- Gregory Serrao
- Steve Liao
Institutions
- Mount Sinai Hospital (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JACC Case Reports
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.jaccas.2025.106044
- Citations
- 1
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.67