Mitochondrial damage and IL-1β production in monocytes caused by Neospora caninum infection are mediated by dense granule protein 7 and prohibitins
These findings indicate that NcGRA7 does not directly modulate NF-κB activation but likely enhances the production of IL-1β and TNF-α through post-transcriptional mechanisms, thereby contributing to the upregulation of NLRP3 expression. Moreover, our results suggest that NcGRA7 influences both the NF-κB and inflammasome pathways through its interaction with host cell prohibitins. Elucidating the roles of PHB1 and NcGRA7 will provide new insights into the host-parasite interactions underlying <i>N. caninum</i> pathogenesis.
Authors
- Naomi Shimoda
- Ryûichi Sawa
- Yoshifumi Nishikawa (ORCID: https://orcid.org/0000-0001-5005-6377)
- Coh-ichi Nihei
- Takumi Koshiba (ORCID: https://orcid.org/0000-0001-8535-5043)
- Mitsuhiro Nishigori (ORCID: https://orcid.org/0009-0002-8713-2681)
- Nanako Ushio-Watanabe (ORCID: https://orcid.org/0009-0002-5603-1669)
- Jingwei Liu (ORCID: https://orcid.org/0000-0001-9024-4292)
- Yu Chen (ORCID: https://orcid.org/0000-0002-1235-4645)
- Shu Nakamura
- Yuko Takahashi (ORCID: https://orcid.org/0000-0002-6419-3302)
Institutions
- Fukuoka University (JP)
- Microbial Chemistry Research Foundation (JP)
- Obihiro University of Agriculture and Veterinary Medicine (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1408992
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Obihiro University of Agriculture and Veterinary Medicine
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science