Identification and validation of icaritin-associated prognostic genes in hepatocellular carcinoma through network pharmacology, bioinformatics analysis, and cellular experiments
Modulation of ICT-targeted genes was found to effectively suppress HCC progression, underscoring their potential value as prognostic biomarkers and ideal therapeutic targets for the treatment of HCC.
Authors
- Weixiong Jian
- Juan Wu
- Yanan Bai
- Xinyu Yang (ORCID: https://orcid.org/0009-0002-6036-8942)
- Yunfeng Yu
- Haobo Yang (ORCID: https://orcid.org/0009-0008-7172-2875)
- Yaru Shi (ORCID: https://orcid.org/0000-0001-8063-3825)
- Jun Qing
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- Integrated Chinese Medicine (China) (HK)
- Hunan Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1693028
- Primary Topic
- Medicinal Plant Pharmacodynamics Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00