Yang-deficiency constitution drives poor outcomes in clear cell renal cell carcinoma by modulating the tumour immune microenvironment
This study highlights the crucial role of YDC in shaping the immune microenvironment and influencing survival in ccRCC. By integrating constitution-based stratification, immune profiling, and herbal medicine screening, we offer a unique framework for biomarker discovery and propose baicalein as a potential YDC-targeted adjuvant therapy.
Authors
- Zongyuan Zhou (ORCID: https://orcid.org/0000-0002-8403-6531)
- Y. Zhang (ORCID: https://orcid.org/0009-0004-8998-5391)
- Guowei Zhou (ORCID: https://orcid.org/0000-0001-8907-9453)
- Yihang Sui
- Yinyin Wang (ORCID: https://orcid.org/0000-0002-0323-5345)
- Huanhuan Lu (ORCID: https://orcid.org/0000-0002-5594-7168)
- Rui Liu (ORCID: https://orcid.org/0000-0003-0802-1917)
- Jiaqi Yao (ORCID: https://orcid.org/0000-0002-7822-910X)
- Boon Seng Kho
- Bo Zhang (ORCID: https://orcid.org/0009-0002-9957-5914)
Institutions
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
- Chengdu University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1673579
- Primary Topic
- Flavonoids in Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Sichuan Province
- Natural Science Foundation for Young Scientists of Shanxi Province
- Young Scientists Fund