Acetylcholine in the gingival epithelium drives the pathogenesis of periodontitis
In conclusion, our results reveal a complex, multifaceted role for acetylcholine in periodontal pathogenesis, highlighting its ability to both protect the epithelial barrier and drive inflammatory tissue destruction. These findings establish a new "neuro-epithelial-immune axis" in the pathogenesis of periodontal disease and reveal potential targets for therapeutic intervention.
Authors
- Shihan Xu (ORCID: https://orcid.org/0000-0002-3950-3815)
- Bin Cheng (ORCID: https://orcid.org/0000-0001-7288-806X)
- Jiaxin Guo (ORCID: https://orcid.org/0000-0002-7692-9620)
- Shiwen Yang (ORCID: https://orcid.org/0000-0001-5469-9695)
- Juan Xia
Institutions
- Sun Yat-sen University (CN)
- Stomatological Hospital of Chongqing Medical University (CN)
- Stomatology Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fcell.2025.1701252
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00