Potential diagnostic markers and therapeutic targets for periodontitis with comorbid infective endocarditis based on bioinformatics and experimental analyses
ITGAM, FCGR3B, FCGR3A, and ITGB2 can serve as mechanistically informative diagnostic biomarkers and promising therapeutic targets for PD-IE comorbidity. The shared pathophysiology of the two diseases involves immune response mechanisms. Our findings open up new avenues for the concurrent therapeutic targeting of both diseases.
Authors
- Xiangyu Zhou (ORCID: https://orcid.org/0000-0003-2115-4175)
- Wei Zhang
- Ting Zhou (ORCID: https://orcid.org/0000-0003-4349-2036)
- Wenjie Zhang (ORCID: https://orcid.org/0000-0002-7753-695X)
- Xuelin Wang (ORCID: https://orcid.org/0000-0001-5750-6035)
- Yutong Liu (ORCID: https://orcid.org/0000-0003-2236-6962)
- Mei Feng (ORCID: https://orcid.org/0000-0001-6605-1941)
Institutions
- Anhui Medical University (CN)
- Wuhan University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fcell.2025.1725544
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00