The crossroads of inflammation and nutrition: predicting neoadjuvant immunochemotherapy efficacy in esophageal squamous cell carcinoma patients
This study demonstrated for the first time that the SII-PNI score can be used as an independent predictor of pCR in patients with ESCC treated with nICT and has prognostic stratification value. This suggests that it has the potential to be a pre-treatment assessment tool for evaluating treatment response and prognosis before nICT treatment.
Authors
- Song Cai (ORCID: https://orcid.org/0000-0003-1482-1291)
- Ying Peng (ORCID: https://orcid.org/0000-0002-4485-8303)
- Yusheng Guo (ORCID: https://orcid.org/0000-0002-5826-299X)
- Guisheng Zhang (ORCID: https://orcid.org/0000-0001-9880-950X)
- Jie Lou (ORCID: https://orcid.org/0009-0006-6064-1450)
- Lian Yang (ORCID: https://orcid.org/0000-0003-4664-2474)
- Zhichao Fu (ORCID: https://orcid.org/0000-0003-0341-106X)
- Yuanji Xu
- Bingxin Gong
Institutions
- Fujian Medical University (CN)
- Henan University of Science and Technology (CN)
- Precision for Medicine (United States) (US)
- Wuhan Union Hospital (CN)
- Fujian Provincial Cancer Hospital (CN)
- Union Hospital (CN)
- Hubei University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1663268
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China