Aqueous humor levels of syndecan-1 and syndecan-4 associated with OCTA metrics in diabetic retinopathy
The differential expression of syndecan-1 and syndecan-4 was observed in the aqueous humor of DR patients, with syndecan-1 being up-regulated and syndecan-4 down-regulated. As DR progresses, retinal large vessel PD showed an increasing trend, while capillaries PD decreased. Moreover, both syndecan-1 and syndecan-4 exhibited correlations with retinal capillaries PD. Syndecan-1, syndecan-4 and OCTA parameters had demonstrated excellent diagnostic efficacy for DR. These results not only expanded the range of potential biomarkers for detecting DR but also provide support for the future development of novel therapeutic targets for this condition.
Authors
- Jianqin Lei (ORCID: https://orcid.org/0000-0001-5304-5972)
- Yazhou Qin
- Xiayu Xu (ORCID: https://orcid.org/0000-0002-5286-0454)
- An-Ming Xie
- Qin Li (ORCID: https://orcid.org/0000-0002-8633-8859)
- Jingming Li (ORCID: https://orcid.org/0009-0004-4875-2110)
- Yue Bian
- Yingdong Qu (ORCID: https://orcid.org/0000-0001-5614-4167)
- Yingni Huang
- Jixian Ma
- Qiuping Liu (ORCID: https://orcid.org/0000-0001-9521-6717)
Institutions
- Northwest University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- First Affiliated Hospital of University of South China (CN)
- First Hospital of Xi'an (CN)
- Xi'an Jiaotong University (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fmed.2025.1712044
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Key Research and Development Projects of Shaanxi Province