Baseline AHR expression shapes immune response to pharmacological modulation in PBMCs from pancreatic cancer patients
Baseline AHR expression critically shapes the immune response to pharmacological modulation in PBMCs from PDAC patients. These findings suggest that AHR profiling may serve as a clinically relevant biomarker for stratifying patients and guiding personalized immunotherapy approaches for PDAC.
Authors
- Agne Sikarske
- Toivo Maimets (ORCID: https://orcid.org/0000-0001-6461-3365)
- Aldona Jasukaitienė (ORCID: https://orcid.org/0000-0002-4606-1963)
- Jason Matthews (ORCID: https://orcid.org/0000-0002-9815-8636)
- Arenida Bartkevičienė (ORCID: https://orcid.org/0000-0003-4682-7620)
- Žilvinas Dambrauskas (ORCID: https://orcid.org/0000-0003-2173-1294)
- Antanas Gulbinas (ORCID: https://orcid.org/0000-0002-6683-1339)
- Darius Stukas
- Astra Vitkauskienė (ORCID: https://orcid.org/0009-0001-6107-9731)
- Kristaps Jaudzems (ORCID: https://orcid.org/0000-0003-3922-2447)
- Daiva Urbonienė (ORCID: https://orcid.org/0000-0002-7920-9856)
- Inga Žievytė
- Sandra Ivanauskienė
- Kornelija Jenceviciute
- Gabrielė Karvelytė
- Gabija Stachneviciute
Institutions
- Lithuanian University of Health Sciences (LT)
- University of Oslo (NO)
- University of Toronto (CA)
- Latvijas Organiskās Sintēzes Institūts (LV)
- University of Tartu (EE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1655258
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lietuvos Sveikatos Mokslų Universitetas