Pathologic Complete Response Predicts Long‐Term Survival Following Neoadjuvant Induction Chemotherapy and Chemo‐Radiotherapy in Stage‐ <scp>III</scp> Non‐Small Cell Lung Cancer
Induction chemotherapy followed by chemo-radiotherapy results in high PCR rates. In this investigation, PCR is followed by high event-free and overall survival rates. These data warrant further investigation of chemo-radiotherapy as a significant component of neoadjuvant treatment regimens in trials combined with immunotherapy. This strategy may increase the PCR rates, particularly for patients with more advanced, potentially resectable stage III NSCLC.
Authors
- Martin Metzenmacher (ORCID: https://orcid.org/0000-0001-5395-9010)
- Benedikt Höing (ORCID: https://orcid.org/0000-0003-1399-6049)
- Marcel Opitz (ORCID: https://orcid.org/0000-0001-7455-8590)
- Faustina Funke
- Dirk Theegarten
- Martin Schüler (ORCID: https://orcid.org/0000-0002-2166-3394)
- Maja Guberina (ORCID: https://orcid.org/0000-0003-3218-0539)
- Christian Taube (ORCID: https://orcid.org/0000-0002-3546-1398)
- Christoph Pöttgen (ORCID: https://orcid.org/0000-0002-9224-9318)
- Nika Guberina
- Servet Bölükbas (ORCID: https://orcid.org/0000-0001-8275-5957)
- Thomas Gauler
- David Kersting (ORCID: https://orcid.org/0000-0002-8451-1830)
- Lale Umutlu (ORCID: https://orcid.org/0000-0001-5215-7171)
- Emil Mladenov
- Gregor Zaun (ORCID: https://orcid.org/0000-0002-3813-6961)
- Anja Merkel‐Jens
- Wolfgang P. Fendler (ORCID: https://orcid.org/0000-0002-5106-3584)
- Christian Pieter Hoffmann (ORCID: https://orcid.org/0000-0002-5282-6950)
- Martin Stuschke (ORCID: https://orcid.org/0000-0001-6836-0940)
- Fabian Doerr (ORCID: https://orcid.org/0000-0002-0878-0406)
- Wilfried Eberhardt (ORCID: https://orcid.org/0000-0003-4284-3586)
- Diana Lütke‐Brintrup
- Hubertus Hautzel (ORCID: https://orcid.org/0000-0002-3581-5264)
- Till Plönes (ORCID: https://orcid.org/0000-0003-4839-2130)
- George Iliakis
- Michael Forsting (ORCID: https://orcid.org/0000-0002-5584-9824)
- Marcel Wiesweg (ORCID: https://orcid.org/0000-0002-9698-9559)
- Clemens Aigner (ORCID: https://orcid.org/0000-0002-7787-991X)
- Cornelius Kürten (ORCID: https://orcid.org/0000-0002-2720-0075)
- Felix Nensa (ORCID: https://orcid.org/0000-0002-5811-7100)
- Aleksandar Milošević (ORCID: https://orcid.org/0000-0003-3601-3287)
- Ken Herrmann
- Georgios Stamatis
Institutions
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- Vienna General Hospital (AT)
- Institut für Medizinische Informatik, Biometrie und Epidemiologie (DE)
- Ruhrlandklinik (DE)
- National Center for Tumor Diseases (DE)
- Luisenkrankenhaus (DE)
- Essen University Hospital (DE)
- Arbeitsgemeinschaft für Klinische Ernährung (AT)
- West German Heart and Vascular Center Essen (DE)
- University Hospital Carl Gustav Carus (DE)
- Artificial Intelligence in Medicine (Canada) (CA)
- University of Duisburg-Essen (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Thoracic Cancer
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1111/1759-7714.70183
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universität Duisburg-Essen