Regulation of intestinal injury via dietary cysteine
Chi and colleagues revealed that dietary cysteine enhances intestinal stem cell (ISC) regeneration, driving coenzyme A (CoA) synthesis and expansion of intraepithelial (IEL) CD8αβ<sup>+</sup> T cells that secrete IL-22. This epithelial-immune crosstalk potentiates ISC repair after injury, highlighting a metabolism-immune axis linking cysteine sensing to tissue regeneration.
Authors
- Nicola Gagliani (ORCID: https://orcid.org/0000-0001-8514-1395)
- Francesco Siracusa (ORCID: https://orcid.org/0000-0001-6047-7351)
Institutions
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
Publication Details
- Journal
- Trends in Immunology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.it.2025.11.003
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission