Integrative analysis identifies PIGK as an oncogenic glycosylphosphatidylinositol transamidase subunit with prognostic, immunological, and therapeutic relevance in head and neck cancer
PIGK functions as a potential oncogenic driver in HNC with prognostic and therapeutic relevance. Its association with FAM20C, taxane response, and modulation of fibroblast activation provides insights into PIGK-mediated oncogenesis and may inform patient stratification strategies.
Authors
- Yi‐Fang Yang (ORCID: https://orcid.org/0000-0001-7425-3156)
- Yu‐Hsuan Lin (ORCID: https://orcid.org/0000-0001-5311-0623)
- Chih-Yu Chou
- Jia-Bin Liao (ORCID: https://orcid.org/0009-0004-4541-9320)
- Pei-Lun Yu
Institutions
- National Sun Yat-sen University (TW)
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Veterans General Hospital (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- International Journal of Medical Sciences
- Published
- 2025-11-20
- DOI
- https://doi.org/10.7150/ijms.121484
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kaohsiung Veterans General Hospital
- National Science and Technology Council