Deciphering the let-7c-5p/RRM2 axis in lung adenocarcinoma: expression, prognosis, and immune landscape implications
Our findings suggest that RRM2 is closely associated with the malignant progression of LUAD and may serve as a potential prognostic biomarker with clinical relevance. Furthermore, the let-7c-5p/RRM2 regulatory axis may play an important role in the development and progression of LUAD, representing a promising therapeutic target that warrants further in-depth investigation.
Authors
- Xuefeng Bian (ORCID: https://orcid.org/0009-0007-4169-3826)
- Xialin Sun
- Lele Li (ORCID: https://orcid.org/0000-0001-8593-9292)
- Xingbo Bian (ORCID: https://orcid.org/0000-0003-1096-1721)
- Jinlong Liu (ORCID: https://orcid.org/0000-0001-9683-9043)
- Yu Han (ORCID: https://orcid.org/0000-0003-4148-2950)
- Xin Sun (ORCID: https://orcid.org/0000-0001-8891-156X)
- Jinying Wu
Institutions
- Jilin Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fonc.2025.1628429
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- People's Government of Jilin Province