Metabolic reprogramming and M2 macrophage depletion define the microenvironment of adenomyosis
This study identifies dysregulation of keratan sulfate biosynthesis as a central feature of adenomyosis and links it to reduced M2 macrophage abundance and immune-metabolic imbalance. Validation of four keratan sulfate related genes strengthens their potential as biomarkers or therapeutic targets, providing novel mechanistic insight into the pathogenesis of adenomyosis.
Authors
- Xinyi Dong
- Zhe Sun (ORCID: https://orcid.org/0000-0003-1872-2194)
- Yun Sun (ORCID: https://orcid.org/0000-0002-9073-8142)
- Xuejiao Bian (ORCID: https://orcid.org/0000-0003-3406-6414)
- Hugo Vankelecom (ORCID: https://orcid.org/0000-0002-2251-7284)
- Hengyu Guan (ORCID: https://orcid.org/0009-0007-6168-285X)
- Boyu Li (ORCID: https://orcid.org/0000-0002-7648-3745)
- Junliang Lai
Institutions
- Renji Hospital (CN)
- Department of Public Health (MM)
- KU Leuven (BE)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fendo.2025.1602814
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00