A case report of tumor-associated liver injury alleviated with antineoplastic drug

Tumors are the major diseases that threaten people's health and life at present. Liver injury often happens in patients with cancer, and which mostly attribute to application of anti-cancer drugs. However, some cases caused by the infiltration and destruction of metastatic cancer, and anti-tumor drugs play a key role in restoring liver function instead of inducing drug induced liver injury (DILI). This article reports a case of tumor-associated Liver Injury (TALI) who suffered HER2-negative metastatic breast cancer with liver metastasis, but her liver function was recovery after treatment with Alpelisib, an anti-tumor drug, as meanwhile as achieving anti-tumor. Through this case we aims to emphasize to differentiate the causes of TALI and make the treatment strategies accordingly.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-11-20
DOI
https://doi.org/10.3389/fonc.2025.1644790
Primary Topic
Drug-Induced Hepatotoxicity and Protection
Type
article
Field-Weighted Citation Impact
0.00

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article

A case report of tumor-associated liver injury alleviated with antineoplastic drug

Shengjuan Yao, Zhiyuan Yang, Liang Xu, Lixia Cao et al.
Frontiers in Oncology
Drug-Induced Hepatotoxicity and Protection
article

A case report of tumor-associated liver injury alleviated with antineoplastic drug

Shengjuan Yao, Zhiyuan Yang, Liang Xu, Lixia Cao, Wentao Kuai, Shuang Li
article en

Abstract

Tumors are the major diseases that threaten people's health and life at present. Liver injury often happens in patients with cancer, and which mostly attribute to application of anti-cancer drugs. However, some cases caused by the infiltration and destruction of metastatic cancer, and anti-tumor drugs play a key role in restoring liver function instead of inducing drug induced liver injury (DILI). This article reports a case of tumor-associated Liver Injury (TALI) who suffered HER2-negative metastatic breast cancer with liver metastasis, but her liver function was recovery after treatment with Alpelisib, an anti-tumor drug, as meanwhile as achieving anti-tumor. Through this case we aims to emphasize to differentiate the causes of TALI and make the treatment strategies accordingly.

Frontiers in OncologyVol. 15
Tianjin Infectious Diseases Hospital (CN), Tianjin People's Hospital (CN), Second Hospital of Tianjin Medical University (CN), Tianjin Medical University (CN)
Natural Science Foundation of Tianjin City
Openalex Percentile: Top 56%
Drug-Induced Hepatotoxicity and Protection
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A case report of tumor-associated liver injury alleviated with antineoplastic drug — Shengjuan Yao, Zhiyuan Yang, et al. · Frontiers in Oncology (2025) | TGRS Research Map | TGRS