Plasma oxytocin and leptin in relation to disordered eating: evidence from non-linear modeling across metabolic obesity phenotypes

Lower oxytocin is associated with greater disordered-eating severity, but oxytocin is most informative when integrated with metabolic and behavioral markers. A multivariable model substantially improved discrimination and net benefit over oxytocin alone. The ~90.5 pg/mL value is an exploratory operating point rather than a clinical cutoff; external validation and prospective evaluation are needed before translation to practice.