Effect of topical papaverine on parathyroid function preservation after total thyroidectomy: a retrospective cohort study
Applying papaverine directly during surgery effectively lowers the risk of early hypoparathyroidism after total thyroidectomy while promoting faster PTH recovery. This method is simple, easy to perform, and has a high safety profile. Future multicenter randomized controlled trials should be conducted to confirm long-term effectiveness and refine the dosing protocol.
Authors
- Xiaonuo Shi
- Wenhao Duan (ORCID: https://orcid.org/0000-0001-5167-488X)
- Yan Yan (ORCID: https://orcid.org/0000-0002-5917-1475)
- Jie Li (ORCID: https://orcid.org/0000-0002-8328-3274)
- Shouhua Zheng
- Yipeng Wang (ORCID: https://orcid.org/0000-0001-9769-9839)
- Binbin Li (ORCID: https://orcid.org/0009-0007-5293-2773)
- Baohua Hou (ORCID: https://orcid.org/0000-0003-4639-8723)
Institutions
- Lanzhou University of Technology (CN)
- Zhengzhou Central Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fendo.2025.1675722
- Primary Topic
- Thyroid and Parathyroid Surgery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Henan Provincial Science and Technology Research Project