A threshold of β-CTX (0.3 ng/mL) with low estradiol identifies high-risk perimenopausal women for bone loss: a cross-sectional study

A clinically meaningful β-CTX threshold (≥ 0.3 ng/mL) was defined for perimenopausal bone loss prediction, and the combination of E2 and β-CTX is a simple and reliable method for predicting perimenopausal bone loss, with high sensitivity and specificity. A threshold of β-CTX (0.3 ng/mL) with low estradiol identifies high-risk perimenopausal women for bone loss.