Independent Role of White Matter Hyperintensity Volume and Location in Alzheimer’s Disease Risk Beyond Hippocampal Atrophy

WMH volume and location independently contribute to AD risk and cognitive decline, with PVWMH and JVWMH particularly affecting executive and memory functions, regardless of hippocampal atrophy.

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Publication Details

Journal
Psychiatry Investigation
Published
2025-11-20
DOI
https://doi.org/10.30773/pi.2025.0127
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Independent Role of White Matter Hyperintensity Volume and Location in Alzheimer’s Disease Risk Beyond Hippocampal Atrophy

Joon Hyuk Park, Hyun Ju Yang, Jae Min Song
Psychiatry Investigation
Dementia and Cognitive Impairment Research
article

Independent Role of White Matter Hyperintensity Volume and Location in Alzheimer’s Disease Risk Beyond Hippocampal Atrophy

Joon Hyuk Park, Hyun Ju Yang, Jae Min Song
article en

Abstract

WMH volume and location independently contribute to AD risk and cognitive decline, with PVWMH and JVWMH particularly affecting executive and memory functions, regardless of hippocampal atrophy.

Psychiatry InvestigationVol. 22(12)
National Institute of Fisheries Science (KR), Jeju National University Hospital (KR), Jeju TechnoPark (KR), Jeju National University (KR)
Jeju National University, Jeju National University Hospital
Openalex Percentile: Top 58%
Dementia and Cognitive Impairment Research
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