Genetic evidence for causal association between platelet count and glioma risk through Mendelian randomization analysis

This study establishes a causal relationship between platelet count and glioma risk through genetic evidence. Increased platelet count confers protection against glioma, including GBM. Suppressed expression of platelet-related genes in glioma cells supports this finding. These results provide new insights into glioma pathogenesis and suggest potential for platelet-based prevention strategies and biomarker development.