Longitudinal risk of cirrhosis by steatotic liver disease subtype among 1.5 million individuals in the US
Given the growing burden of steatotic liver disease (SLD) in the US, it is crucial to understand how different causes - namely alcohol use and metabolic dysfunction - contribute to the risk of developing cirrhosis. This large, national study demonstrates that patients with alcohol-related liver disease face the highest risk, with notable variation by race and ethnicity. These findings are especially important for clinicians and healthcare systems caring for diverse populations, as they highlight groups at elevated risk who may benefit from targeted prevention and early intervention strategies. Practically, these results support the need for integrated care approaches that address both harmful alcohol use and metabolic conditions like obesity and diabetes to reduce progression to advanced liver disease.
Authors
- Saleh A. Alqahtani (ORCID: https://orcid.org/0000-0003-2017-3526)
- Robert J. Wong (ORCID: https://orcid.org/0000-0002-8923-2806)
- Mai Sedki (ORCID: https://orcid.org/0000-0003-4243-8548)
- Aleksander Krag (ORCID: https://orcid.org/0000-0002-9598-4932)
- Mário Guimarães Pessôa (ORCID: https://orcid.org/0000-0002-0942-7348)
- Linda Henry (ORCID: https://orcid.org/0000-0002-7833-6124)
- Zobair M. Younossi (ORCID: https://orcid.org/0000-0001-9313-577X)
- Ashwani Kumar Singal (ORCID: https://orcid.org/0000-0003-1207-3998)
- Zeyuan Yang (ORCID: https://orcid.org/0000-0001-5067-7560)
- Jörn M. Schattenberg (ORCID: https://orcid.org/0000-0002-4224-4703)
- Jeffrey V. Lazarus (ORCID: https://orcid.org/0000-0001-9618-2299)
Institutions
- Inova Health System (US)
- The Graduate Center, CUNY (US)
- Alfaisal University (SA)
- University of Louisville (US)
- Johns Hopkins University (US)
- Universidade de São Paulo (BR)
- VA Palo Alto Health Care System (US)
- Odense University Hospital (DK)
- Jewish Hospital (US)
- Louisville VA Medical Center (US)
- Center for Outcomes Research in Liver Diseases (US)
- University of Louisville Hospital (US)
- Barcelona Institute for Global Health (ES)
- Universitat de Barcelona (ES)
- Saarland University (DE)
- Stanford University (US)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101680
- Citations
- 1
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- U.S. Department of Veterans Affairs
- Pfizer
- Gilead Sciences
- City University of New York
- Johns Hopkins University
- University of Louisville
- Inova Health System
- Centres de Recerca de Catalunya
- Moderna
- King Faisal Specialist Hospital and Research Centre
- Generalitat de Catalunya
- Novo Nordisk
- Odense Universitetshospital
- Universität des Saarlandes
- Universidade de São Paulo
- Universitat de Barcelona
- Ipsen
- Alfaisal University
- School of Medicine, Stanford University
- Agencia Estatal de Investigación