Professional needs regarding cannabis: Learning about the endocannabinoid system and cannabinoid pharmacology

The endocannabinoid system (ECS) is a physiological system consisting of cannabinoids receptors (CBs), endogenous lipid-based ligands, known as endocannabinoids, and the enzymes responsible for synthesis and metabolism. Unlike other systems, the discovery of the ECS was relatively recent. Therefore, for many health professionals that currently support the use of medical cannabis for their patients, their knowledge about the ECS and cannabinoid pharmacology was independently acquired. This manuscript aims to provide foundational information about the ECS and cannabinoid pharmacology, advocate for increased education on these topics among all healthcare providers, particularly in regions with established medical cannabis programs, and to promote the inclusion of ECS-related content in curricula of biomedical education programs (e.g., medical, veterinary, pharmacy, nursing). We also recommend a consistent use of the term cannabis in place of marijuana as it reflects the plants’ formal name and helps avoid historical stigma. Staying informed about the ECS and cannabinoid pharmacology empowers healthcare professionals to offer optimal guidance regarding product selection, therapeutic efficacy, dosing, administration methods, and management of potential drug interactions and adverse effects.