Regulation of HDL dysfunctionality by phosphatidylethanolamine links poly-unsaturated fatty acids with atherosclerotic cardiovascular diseases
This study reveals a causal link between PE species, particularly ARA-PE, and HDL dysfunction, contributing to atherosclerosis. EPA-PE can restore HDL function, supporting the therapeutic potential of EPA reducing ASCVD risk.
Authors
- Wilfried Le Goff (ORCID: https://orcid.org/0000-0002-7611-9644)
- Maryse Guérin (ORCID: https://orcid.org/0000-0003-0150-1360)
- Éric Frisdal
- Pukar KC (ORCID: https://orcid.org/0000-0002-8690-1795)
- Isabelle Guillas (ORCID: https://orcid.org/0000-0002-6073-0529)
- Philippe Lesnik (ORCID: https://orcid.org/0000-0002-6909-7715)
- Maharajah Ponnaiah (ORCID: https://orcid.org/0000-0001-7761-4228)
- Philippe Giral (ORCID: https://orcid.org/0000-0002-1863-1711)
- Marie Lhomme (ORCID: https://orcid.org/0000-0002-6335-4506)
- Hervé Durand (ORCID: https://orcid.org/0000-0002-8167-4693)
- Jean-Paul Paı̈s de Barros (ORCID: https://orcid.org/0000-0002-5124-2283)
- Laurent Kappeler (ORCID: https://orcid.org/0000-0001-7971-0838)
- Clément Materne (ORCID: https://orcid.org/0000-0003-2605-2231)
- Anatol Kontush (ORCID: https://orcid.org/0000-0002-9008-7335)
- Antonio Gallo (ORCID: https://orcid.org/0000-0002-8887-994X)
- Sophie Galier (ORCID: https://orcid.org/0000-0002-8094-3409)
- Veronica D. Dahik (ORCID: https://orcid.org/0000-0003-3746-0281)
- Malik Taradeh
- David Masson (ORCID: https://orcid.org/0000-0003-1692-0699)
- Eric Bun
- Eric Bruckert
- Maud Clemessy
- Petra El Khoury
- Canelle Reydellet (ORCID: https://orcid.org/0009-0002-9445-7206)
- Lise Hardy (ORCID: https://orcid.org/0000-0002-3598-2812)
- Elise F. Villard
- Hua Wang (ORCID: https://orcid.org/0000-0002-7319-6249)
Institutions
- Inserm (FR)
- Université de Bourgogne (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- CHU Dijon Bourgogne (FR)
- Pitié-Salpêtrière Hospital (FR)
- Centre de recherche Translationnelle en Médecine moléculaire (FR)
- Laboratoire d'étude de l'apprentissage et du développement (FR)
- Fondation pour l’innovation en Cadiométabolisme et Nutrition (FR)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.molmet.2025.102281
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00